Topical Tropical – Mystery Disease In Congo

Topical Tropical – Mystery Disease In Congo

As I write in mid-December this is the hottest trending subject in the world of tropical disease. By the time you read it, the disease may have been long ago diagnosed, explained and tucked away as another outbreak in a remote part of Africa. No matter. It won’t be the last. Mystery diseases still arise. It may take all the resources of the specialists in WHO and CDC to get to the bottom of them. It takes time, it’s complicated, and will happen again.

This is from the WHO in December …as of 5 December 2024, Panzi health zone in Kwango Province has recorded 406 cases of an undiagnosed disease with symptoms of fever, headache, cough, runny nose and body ache and 31 deaths (Case Fatality Ratio or CFR of 7.6%). It goes on to say that although 80% of the cases tested positive for malaria, malaria alone could not be responsible for the outbreak. All the reported deaths were malnourished and almost all under 5. This is no surprise as in an area such as Kwango Congo, children are going to be bitten by an infected mosquito five or six times every night. They have partial immunity: so although they are constantly exposed, their immune system prevents them developing the full-blown disease. They will sometimes have enough parasites floating around to make a positive malaria rapid test but they are not sick.

Malaria and malnutrition are immunosuppressive conditions so both together could make them more susceptible to severe illness from another infectious disease, that is not causing deaths in well fed older children and adults.

It may be a surprise that we can have mystery diseases that are still not diagnosed after 2 months despite a full mobilisation of CDC and WHO. Surely modern medicine has lab tests that can tell us what’s wrong in just a few days?

Actually no

I can remember 2010 when an unknown disease started causing deaths in districts around Gulu.

Unveiling the Mystery

CDC were quick to respond and began tracking down the deaths. The first cluster were in those who attended the funeral of the first case of Ebola so of course Ebola was uppermost in our minds. They tested everyone with fever and I remember my colleague in Entebbe telling me that “all the 20 causes of fever you would expect” were prevalent in the district. Eventually they established that the outbreak was due to yellow fever. It took 6 weeks: but I was assured that in such circumstances this was a very quick result. In Congo the prevailing consensus at this time is the outbreak is a new flu-like illness with many factors combining to cause deaths in a vulnerable population. I also noted that it was reported the first cases were diagnosed as” malaria and typhoid”. These 2 “mystery outbreaks” 15 years apart tell us a lot about health care and the problem with getting the right diagnosis. There are “20 causes of fever” out there but too often they are diagnosed as “malaria and typhoid” and the experts have to be called in.

So, what are the experts doing? What all physicians should always be doing. Start with history, then examination and then relevant lab tests. “Who where when” is the bedrock of good epidemiology and good medicine.

Topical Tropical Mystery Disease In Congo Nature
Topical Tropical Mystery Disease In Congo Nature

A lot of medical mistakes are the result of neglecting the history, not bothering with a proper examination and instead going straight to lab tests and hi-tech imaging. So regardless of what the WHO and CDC find in Congo it’s important to make sure that when you or your children have a fever you get the right diagnosis. A tripod is stable and can’t wobble. The first leg of the tripod, the first pillar of good medical care is a proper history. Who where when. Who: who is the patient? Are they a new arrival, a child, a tourist or a local office worker? Who have they been in contact with? Sick children, refugees, nursing an old lady with TB? Where: have they been in the lake, have they been visiting the slums, have they been in Sudan, have they been nowhere except the office and home in the past month? Have they been sleeping outside, what might have bitten or stung them, where have they been eating? Which restaurant, on the street? In the village? When? When was the first symptom, how long did it last, what other symptoms, when was the cough, the diarrhoea, the vomiting? Which came first? Were they visiting somewhere inside the incubation period of a disease: 3 to 6 weeks for bilharzia, 8 days for malaria, 2 days for a flu or Covid? I remember our “oops” moment when we found a 40-degree fever and cough in someone 3 days after riding a camel in Dubai. Straight into isolation. Sample for MERS sent off urgently. It is neglect of this first pillar, history, that causes so many embarrassing mistakes: I can remember a doctor telling his patients that they see malaria in people from Europe who have been in Uganda 2 days. Absolutely impossible. Most of those 20 diseases that my old CDC friend told me they found in the villages of Acholi in 2010 are not going to be found in an office worker in Nakasero. I don’t want to be pretentious and list the 20 but Leptospirosis, Borellia, Ricketsia, Brucellosis, Coxiella, salmonella, shigella, TB, Bilharzia, 3 or 4 named arboviruses, are all common enough to be seen every week or 2 in travellers and people coming back from up country. If they are not listed in monthly reports it’s probably not because they are not seen, it’s because they are not diagnosed. Then add on the normal non-tropical fevers that we see everywhere: Covid, flu, RSV, mononucleosis, hepatitis. 20 is no exaggeration, but who where when can narrow it down.

Examining the Essentials

The second leg is examination. Temperature pulse, blood pressure, respiratory rate must be measured and recorded. A bare minimum is general assessment, check anaemia, jaundice, lymph nodes, rash. Look in the throat, children the ears, listen to the chest, tap and palpate the abdomen. Personally, I found a pulse ox is so quick and easy there is no excuse for not doing it. The oxygen concentration may well be normal in almost everyone, but if it’s found to be low the next day it’s rather important to know what it was when they came in. Only when we already have a clear idea of what it might be from the history and exam do we go to the third pillar. A typical short cut is “What’s wrong? Fever and headache. Do a blood test for malaria and typhoid.” There is no place for such negligence in modern medicine. The third pillar is simple quick relevant lab tests. The most important tests are out in 10 minutes. A whole range of expensive tests to look good and make money is not good practice, especially if it means they are not giving results until tomorrow. Sure, take the samples and the tests can be done later if necessary; but a blood count, malaria rapid, urine dip test, rapid bilharzia test, all these take 10 minutes. It might tell us what you have, or it might tell us what you don’t have. I remember when we found a case of trypanosomiasis from Jinja about 10 years ago. It really did take less than10 minutes looking down a microscope, the slide was a crawling with them. Beautiful if you like that sort of thing. They insisted on medivac and Nairobi took 2 days to confirm because we had already treated it before they left, so tryps were no longer visible.

Topical Tropical Mystery Disease In Congo Insect

Warnings

“Malaria and typhoid” is extremely unlikely

and in 42 years I never saw both cases together. The diagnosis was almost always due to a “positive” blood slide which was probably wrong. Malaria rapid tests are extremely accurate, the CDC publicly claims they are 100% accurate. A negative test, especially if repeated in 24 hours, means it is absolutely not the dangerous species, falciparum malaria. The rare species, p. vivax or p. Malariae, can be missed by the rapid, but as they are mild variants it doesn’t matter if they are missed for 24 hours, and a urine dip for urobilinogen can arouse enough suspicion for a more careful search. But essentially a negative rapid test means it’s not malaria. Demand to see the test yourself. It’s not rocket science; one line means negative. Typhoid is suggested clinically by a slow climbing fever, headache, almost always cough and abdominal pain. The modern tests can rule it out, a culture is still best to confirm and that takes 2 days. The old Widal tests are utterly unreliable: they are positive for life in anyone who has had salmonella food poisoning twice. And that means almost everyone. A diagnosis of typhoid using a Widal is meaningless. They’re still used so don’t be fooled. There is no such diagnosis as “bacterial infection”. It usually means an automated cell counter has found an elevated white count or just an elevated neutrophil percentage. It can be due to absolutely anything including stress or exercise. It was the latest fad diagnosis 5 years ago: I hope it has already been confined to the dustbin of history. Of course, many fevers are indeed caused by bacterial infections, but it isn’t a diagnosis. It has to be bacterial infection OF something: the diagnosis is tonsillitis or pneumonia, or intestinal infection, or meningitis. Some of those 20 diseases are caused by bacteria. In some bacterial diseases the white count is high, in others the diagnostic clue is the white count is low. Automated cell counts are absolutely a vitally important diagnostic tool but requires proper evaluation. Looking at a white count and saying “bacterial infection” is certainly not making a proper diagnosis.

So, what does this mean for you?

The CDC and WHO experts do it properly: and so can any doctor who chooses to. CDC have the facilities to do extremely expensive tests in labs 500 km away to discover rare or new disease. But they start with the 3 pillars. For most of us, fevers in the tropics can be diagnosed with enough evidence to initiate effective treatment, by using simple diagnostic tools and a modicum of common sense. There is no justification for calling every fever malaria, typhoid and bacterial infection, nor treating everyone with antimalarials and the latest most fashionable antibiotic. Good medicine can still be practiced in a grass thatch facility 100 km from the nearest tarmac: CDC experts do, and so can we all. A proper diagnosis of a fever in the tropics is vital and could be life saving. Don’t be taken in by poor medical standards just because it’s delivered in a shiny environment. If the 3 pillars of good diagnostic practice, history, exam, simple lab tests, are not being clearly followed then why not? If you get given a diagnosis that makes you suspicious try google. If you have the choice, try somewhere else.

If you’re up country phone: 0752 756 003.

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